Omas Disease: Treatment, Symptoms And Causes!

New limb and eye movements, atypical behaviors, sleep dysregulation, and speech impairment are hallmarks of opsoclonus-myoclonus-ataxia syndrome (OMAS), an autoimmune illness of the nervous system. Both viruses and tumours have been implicated as potential causes of OMAS (neuroblastoma). OMAS is classified as a paraneoplastic syndrome because it might be brought on by a tumor.

Symptoms Of OMAS

  • Frequent blinking that cannot be controlled (opsoclonus)
  • Faint, involuntary muscular twitch (myoclonus)
  • Inability to regulate one’s muscles or coordinate one’s actions (ataxia)
  • Imprecise gait (unsteady gait)
  • Disruptions in sleep (insomnia)
  • Alterations in conduct (irritability, rage, etc.)
  • Dilemmas in Expressing Thoughts in Words (slurring, hard to understand, inability to speak)
  • Weakened muscle tone
  • Discomforts associated with nausea and throwing up
Omas Disease
Omas Disease

Causes Of OMAS

OMAS may originate from a response to a viral disease or a tumor called neuroblastoma. When this happens, antibodies are made in the body that attacks the cerebellum, which is in the lower back of the brain. If the cerebellum is damaged, the patient will have trouble walking, their eye movements will be erratic, and they will lose their developmental skills.

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Testing And Diagnosis Of OMAS

Multiple examinations of your child’s brain and body will be performed to confirm the diagnosis of OMAS. Examining the spinal fluid for signs of an immune response is a common reason for a lumbar puncture. Tests for tumor markers, such as vanillylmandelic acid (VMA) and homovanillic acid (HVA), are conducted on urine samples. To fully investigate the possibility of a tumor, other tests, such as a metaiodobenzylguanidine (MIBG) scan, which requires the injection of a very small amount of radioactive material, may be required.

Omas Disease
Omas Disease

Treatment For OMAS

If a tumor is discovered in an individual with OMAS, surgical removal and chemotherapy are the standard treatments. Rituximab is an antibody therapy used to treat autoimmune illnesses, and it is often necessary to utilize steroids, intravenous immunoglobulin, or this drug to “reset” the immune system. Physical and occupational therapy are often included in the treatment of opsoclonus-myoclonus to hasten the patient’s recovery.

Outcomes For Children With OMAS

Some children with OMAS may still struggle with issues related to attention, cognition, and motor control. The best chance for a complete recovery is with prompt medical attention.

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